Thursday, April 2, 2015
4:30 p.m.

Lecture I:

R. Graham Cooks, Purdue University

Chemical and Materials Synthesis with the Mass Spectrometer

Location: Carnegie Mellon University, Department of Chemistry, Mellon Institute, 4400 Fifth Ave. Conference Room on the 3rd floor, Enter from Bellefield Street.

Free and open to the public.

Host: Mark E. Bier

 

The presentation deals with preparative mass spectrometry—the use of the ionization and separation methods of mass spectrometry to prepare macroscopic amounts of material. These experiments include bimolecular reactions in confined volume solutions (such as electrosprayed droplets or thin solution films) which have been scaled up to produce tens of mg amounts of chemical products which are characterized by NMR, SERS, and by analytical MS. This new solution-phase ion chemistry is readily incorporated into undergraduate teaching labs because it is performed with ordinary solvents in the ambient environment and closely resembles conventional solution-phase chemistry, except for its much accelerated time scale. The rates, mechanisms and intermediates are discussed for typical reactions like Girard derivatization, Claisen-Schmidt condensation, Hantzsch synthesis and Negishi coupling. Ion soft landing and ion/surface reactions are shown to allow novel chemical species to be deposited at surfaces, chemical patterns to be written on surfaces and surface-enhanced Raman films to be prepared.

Thursday, April 2, 2015

Lecture II:

R. Graham Cooks, Purdue University

Mass Spectrometry

5:45 p.m. — Bar Social Hour
6:45 p.m. — Dinner (Must RSVP)
7:45 p.m. — Lecture. Free to the public.

Location: Pittsburgh Athletic Assoc., 4215 Fifth Avenue, Oakland. Free parking in the PAA lot for the first 40 cars with token picked up inside.

• Parking is free in the PAA lot for the first 40 cars—pick up token inside.
• Dinner is complimentary for the first 60 pre-registered guests and FREE for students who RSVP until the max attendance is reached, otherwise dinner is $20. Pay at the door with cash or check made out to SSP or SACP.

RSVP by noon on Friday, March 27th to Sara Wainer swainer@andrew.cmu.edu with dinner choice of crab cakes, chicken marsala, or grilled vegetables.

This talk sketches recent rapid progress in mass spectrometry as an analytical method, focusing on its use in intrasurgical tissue analysis (tumor margins and tumor types) and in point-of-care diagnostics (therapeutic drug levels in blood). These two areas of endeavor form the basis for an enquiry into mass spectrometry as well as its relationship to analytical chemistry and to spectroscopy.