Thursday, February 11, 2016
Jay Schneekloth, National Cancer Institute
Targeting Functionally and Structurally Diverse RNAs with Druglike Small Molecules
Host: Bruce Armitage
Researchers led by Carnegie Mellon University’s Molecular and Biosensor Imaging Center (MBIC) Director Marcel Bruchez have re-engineered a fluorescent probe into a powerful optogenetic photosensitizer that can be used to manipulate cells. The technology could help researchers better understand the role certain cells and proteins play in everyday function and disease, and could possibly be used as a targeted therapy for cancer and other diseases. Their findings were published online today by Nature Methods.
Startup Sharp Edge Labs turns business plan upside down
Drug company — co-founded by Associate Professor of Biological Sciences and Chemistry Marcel Bruchez — went from selling patented dyes to creating in-house cures
From Paris, France, to Pittsburgh, Pa., and everywhere in between, there is concern about climate change. Neil Donahue, a renowned Carnegie Mellon University scientist, says that is for good reason, which is why he endorses the world taking action on global and regional levels.
Fluorescent probes, glowing tags that can be attached to a variety of biomolecules, are ubiquitous in the study of biological systems. Chemists at Carnegie Mellon University have developed a new polymer-based probe, inspired by a bottlebrush, that can hold thousands of fluorescent molecules, making it 10 times brighter than current technology. Brighter probes like this will allow scientists to detect very low levels of protein expressed in cells.
Carnegie Mellon University has been named among the top 10 universities worldwide for physical sciences in the 2015-2016 Times Higher Education World University Rankings. The number 10 ranking reflects the university’s excellence in areas including chemistry, mathematics and physics.