The Ly Group

Bioorganic Chemistry  •  Combinatorial Chemistry  •  Chemical Genetics  •  Functional Genomics


Chemical Syntheses

Our chemical synthesis program is focused on function, rather than on methodology development. These targeted molecules, which span over a wide range of chemical space, are designed for specific purposes—using a combination of solution and solid-phase methodologies. Examples of these targeted molecules include fluorescent dyes for labeling, probing and monitoring protein and nucleic acid localizations and dynamics; natural products for modulating protein-protein and protein-nucleic acid interactions; natural biopolymers (DNA and RNA, proteins, and carbohydrates) and their synthetic derivatives for a variety of applications in biology and medicine, including gene regulation, molecular therapies, and cancer vaccine development.