The Ly Group

Bioorganic Chemistry  •  Combinatorial Chemistry  •  Chemical Genetics  •  Functional Genomics


Molecular Engineering


This aspect of our work is focused on the development of molecular recognition codes for programming molecular self-assembly. Specifically, we are working toward developing relatively short (3-5nt in length) and orthogonal nucleic acid recognition codes for organizing and assembling materials in aqueous solution, as well as in organic solvents. The work involves syntheses of conformationally-constrained, β-peptide and related backbones and modified nucleobases, evaluation of recognition properties, and exploration of their utility in biomedical and tissue engineering and in molecular electronics.