The Ly Group

Bioorganic Chemistry  •  Combinatorial Chemistry  •  Chemical Genetics  •  Functional Genomics


Cellular Delivery

cell delivery diagrams

Our on-going work in this area is focused on the design and testing of synthetic reagents for delivery of molecular cargos into the cytoplasmic and nuclear compartments of cells. In addition to being able to deliver these exogenous molecules into live cells and intact organisms for therapeutic and diagnostic applications, we are interested in gaining a better understanding of the mechanisms by which they traverse the extracellular and nuclear membranes of mammalian cells, normal and diseased states, in attempts to further improve the efficiency and selectivity of cellular delivery. One particular class of molecules that we are currently honing is peptide nucleic acid (PNA), as a molecular platform for regulating gene expression.