The Ly Group

Bioorganic Chemistry  •  Combinatorial Chemistry  •  Chemical Genetics  •  Functional Genomics


Peptide Therapeutics

The notion of using peptides and peptidomimetics as drug candidates for treating genetic and infectious diseases is appealing because of the ease and flexibility of synthesis, and the large sequence space that can be generated from a limited number of chemical building blocks; however, the main drawbacks are conformational flexibility and enzymatic stability. Because of their small size and high degree of conformational freedom, they neither binding with high affinity nor selectivity; and moreover, they are easily degraded by proteases. Inspired by nature, in particular the synthesis of 'cyclotides', our group is currently working on the design of template-based strategy for construction of cyclic and knotted-structure peptides as possible antibiotics and other drug candidates.