The Ly Group

Bioorganic Chemistry  •  Combinatorial Chemistry  •  Chemical Genetics  •  Functional Genomics


Infectious Diseases

Work in this area is focused on the development of novel nucleic acid reagents, relatively small in size (3-5nt in length), that preferentially recognize and bind secondary structures of RNA over the linear counterparts. Such molecules are valuable as molecular tools for basic research in biology, as well as remedies for treating genetic and infectious diseases with rapidly evolving targets such as cancer, bacterial and viral infections. The strategy, based on the concept of 'pot-hole fixing', utilizes 16 different combinations of Janus nucleobases to repair the mismatched hydrogen-bonding interactions within RNA molecules.