- Raman Bahal, Bichismita Sahu, Srinivas Rapireddy, Chong-Min Lee, and Danith H. Ly Sequence-Unrestricted, WatsonˆCrick Recognition of Double Helical B-DNA by (R)-MiniPEG-gammaPNAs. Chembiochem, 2012, 13, 56 ˆ 60. (download pdf)
- Bichismita Sahu, Iulia Sacui, Srinivas Rapireddy, Kimberly J. Zanotti, Raman Bahal, Bruce A. Armitage, and Danith H. Ly "Synthesis and Characterization of Conformationally Preorganized, (R)-Diethylene Glycol-Containing γ-Peptide Nucleic Acids with Superior Hybridization Properties and Water Solubility" J. Org. Chem. (ASAP articles) (download pdf)
- Srinivas Rapireddy, Raman Bahal, and Danith H. Ly, "Strand Invasion of Mixed-Sequence, Double-Helical B-DNA by γ-Peptide Nucleic Acids Containing G-Clamp Nucleobases under Physiological Conditions" Biochemistry 2011, 50, 3913–3918 (download pdf)
- Joanne I. Yeh, Boris Shivachev, Srinivas Rapireddy, Matthew J. Crawford, Roberto R. Gil, Shoucheng Du, Marcela Madrid, and Danith H. Ly "Crystal Structure of Chiral γPNA with Complementary DNA Strand: Insights into the Stability and Specificity of Recognition and Conformational Preorganization" J. Am. Chem. Soc., 2010, 132, 10717–10727. (download pdf)
- Lusvarghi, S., Murphy, C,T., Roy, S., Tanious, F,A., Sacui, I., Wilson, W,D., Ly, D. H. Armitage . B,A. “Loop and Backbone Modifications of Peptide Nucleic Acid Improve G-Quadruplex Binding Selectivity” J. Am. Chem. Soc., 2009, 131 (51), pp 18415–18424 (download pdf)
- He, G., Rapireddy, S., Bahal, R., Sahu, B., and Ly, D. H. “Strand Invasion of Extended, Mixed-Sequence B-DNA by γPNAs” J. Am. Chem. Soc. 2009, 131, 12088–12090. (download pdf)
- Sahu, B., Chenna, V., Lathrop, K.L., Thomas, S.M., Zon, G., Livak, K, J., Ly, D. H. “Synthesis of Conformationally Preorganized and Cell-Permeable Guanidine-Based γ-Peptide Nucleic Acids (γGPNAs)” J. Org. Chem., 2009, 74, 1509–1516. (download pdf)
- Wu, Z., Lanni, E., Chen, W., Bier, M,E., Ly, D. H. Jin, R. “High Yield, Large Scale Synthesis of Thiolate-Protected Ag7 Clusters” J. Am. Chem. Soc., 2009, 131, 16672–16674. (download pdf)
- Chenna, V., Rapireddy, S., Sahu, B., Ausin, C., Pedroso, E., Ly, D. H. “A Simple Cytosine to G-Clamp Nucleobase Substitution Enables Chiral -PNAs to Invade Mixed-Sequence Double-Helical B-form DNA” ChemBioChem., 2008, 9, 2388–2391. (download pdf)
- Rapireddy, S., He, G., Roy, S., Armitage . B,A. Ly, D. H. “Strand Invasion of Mixed-Sequence B- DNA by Acridine-Linked, γ-Peptide Nucleic Acid (γ-PNA)” J. Am. Chem. Soc., 2007,129, 15596–15600. (download pdf)
- Zhou, P., Dragulescu-Andrasi, A., Bhattacharya, B., Hyldig-Nielsen, J. J., Ly, D. H. “Synthesis of cell-permeable peptide nucleic acid monomers and oligomers, and characterization of their hybridization and uptake properties”. Bioorg. Med. Chem. Lett. 2006, 16, 4931–4935. (download pdf)
- Dragulescu-Andrasi, A., Rapireddy, S., Frezza, B. M., Gayathri, C., Gil, R. R., Ly, D. H. “A simple γ-backbone modification preorganizes peptide nucleic acid into a helical structure.” J. Am. Chem. Soc. 2006, 128, 10258–10267. (download pdf)
- Dragulescu-Andrasi, A., Rapireddy, S., He, G., Bhattacharya, B., Hyldig-Nielsen, J. J., Zon, G., Ly, D. H. “Cell-permeable peptide nucleic acid designed to bind to the 5’-untranslated region of E-cadherin transcript induces potent and sequence-specific antisense effects”. J. Am. Chem. Soc. 2006, 128, 16104–16112. (download pdf)
- Dragulescu-Andrasi, A., Zhou, P., He, G., Ly, D. H. “Cell-Permeable GPNA Containing Appropriate Backbone Stereochemistry and Spacing Binds Sequence-Specifically to RNA” Chem. Comm. 2005, 244–246. (download pdf)
- Lagerholm, C. B., Wang, M., Ernst, L. A., Ly, D. H. Bruchez, M. P., Waggoner, A. S. “Multicolor Coding of Cells with Cationic Peptide Coated Quantum Dots” Nano Lett. 2004, 4, 2019–2022. (download pdf)
- Zhou, P., Wang, M., Du, L., Fisher, G., Waggoner, A., Ly, D. H. “Novel Binding and Efficient Cellular Uptake of Guanidine-Based Peptide Nucleic Acid (GPNA)” J. Am. Chem. Soc. 2003, 125, 6878–6879. (download pdf)
- Simbulan-Rosenthal, C.M., Ly, D.H., Rosenthal, D.S., Konopka, G., Luo, R-B., Wang, Z-Q., Schultz, P.G., Smulson, M.E. “Misregulation of Gene Expression in Primary Fibroblasts Lacking Poly(ADP-ribose) Polymerase” Proc. Nat. Acad. Sci. 2000, 97, 11274–11279. (download pdf)
- Ly, D.H., Lockhart, D.J., Schultz, P. G., Lerner, R. A. “Mitotic Misregulation and Human Aging” Science. 2000, 287, 2486–2492. (download pdf)
The Ly Group
Bioorganic Chemistry • Combinatorial Chemistry • Chemical Genetics • Functional Genomics
