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  Carnegie Mellon University

Bier Research Group


Book Chapters

  1. Bier, M.E., "2D Quadrupole Field Ion Trap Mass Spectrometers", D. Sparkman and J.T. Watson Editors. Encyclopedia of Mass Spectrometry, Vol. 7, Submitted, pub. expected 2014.
  2. Bier, M.E. "Coupling ESI and MALDI Sources to the Quadrupole Mass Filter, Quadrupole Ion Trap, Linear Quadrupole Ion Trap and Orbitrap Mass Analyzers", Chapter 9 in Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities and Biological Applications, Cole, R. Ed., John Wiley & Sons, New York, 2nd Edition, 2010, p265-245.
  3. Bier, M. E. and Grabowski, J. J. "Active Learning Using the Virtual Mass Spectrometry Laboratory" in ACS Symposium Series Book on Active Learning. 2007, 970 (Active Learning), 171-187.
  4. Bier, M.E. "Analysis of Proteins by Mass Spectrometry", Modern Protein Chemistry: Practical Aspects / Catalog Number 9453; Brown, W.E.; Howard, G.C. (Eds.) CRC Press LLC; Boca Raton, FL; 2002, 71-101.
  5. Bier, M.E. and Schwartz, J.C. "Electrospray Ionization Quadrupole Ion Trap Mass Spectrometry" Chapter 7 in Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation, and Applications, Cole, R. Ed., John Wiley & Sons, New York 1997, 235-289.

Recent Publications

  1. Sipe, D.M.; Plath, L.D.; Aksenov, A.A.; Feldman, J.S.; Bier, M.E. Characterization of Mega-Dalton-Sized Nanoparticles by Superconducting Tunnel Junction Cryodetection Mass Spectrometry. ACS Nano. 2018, 12, 2591-2602.
  2. Plath, L.D.; Wang, Z.; Yan, J.; Matyjaszewski, K; Bier, M.E. Characterization of ZnO Nanoparticles Using Superconducting Tunnel Junction Cryodetection. J. Am. Soc. Mass Spectrom. 2017, 28, 1160-1165.
  3. Plath, L.D.; Ozdemir, A.; Aksenov, A.A.; Bier, M.E. Determination of Iron Content and Dispersity of Intact Ferritin by Superconducting Tunnel Junction Cryodetection Mass Spectrometry. Anal. Chem. 2015, 87, 8985-8993.
  4. Groner, M.L., L.A. Rollins-Smith, L.K. Reinert, J. Hempel, M.E. Bier, and R.A. Relyea, Interactive effects of competition and predator cues on immune responses of leopard frogs at metamorphosis., The Journal of Experimental Biology 2013.
  5. Groner, M.L., J.C. Buck, S. Gervasi, A.R. Blaustein, L.K. Reinert, L.A. Rollins-Smith, M.E. Bier, J. Hempel, and R.A. Relyea, Larval exposure to predator cues alters immune function and response to a fungal pathogen in post-metamorphic wood frogs., Ecological Applications 2013, 23(6), 1443-1454.
  6. Hovis,Kenneth R.; Ramnath, Rohit; Dahlen, Jeffrey E.; Romanova, Anna L.; LaRocca, Greg; Bier, Mark E.; Urban, Nathaniel N., Activity regulates functional connectivity from the vomeronasal organ to the accessory olfactory bulb, Journal of Neuroscience 2012, 32(23), 7907-7916.
  7. Shen, Longzhu Q; Beach Evan S; Xiang, Yan; Tshudy, Dwight J; Khanina, Natalya; Horwitz, Colin P; Bier, Mark E; Collins, Terrence, Rapid, biomimetic degradation in water of the persistent drug sertraline by TAML catalysts and hydrogen peroxide, Environmental Science & Technology 2011, 45(18), 7882-7.
  8. Qian, Huifeng; Eckenhoff, William; Bier, Mark E.; Pintauer, Tomislav; Jin, Rongchao, Crystal Structures of Au2 Complex and Au25 Nanocluster and Mechanistic Insight into the Conversion of Polydisperse Nanoparticles into Monodisperse Au25 Nanoclusters, Inorganic Chemistry, 2011 50(21), 10735-10739.
  9. Wu, Zhikun; Jiang,De-en; Lanni, Eric; Bier, Mark E.; Jin, Rongchao. Sequential Observation of AgnS4- (1 ≤ n ≤7) Gas Phase Clusters in MS/MS and Prediction of Their Structures. Journal of Physical Chemistry Letters 2010, (9),1423-1427.
  10. Stephens, Catherine H.; Shrestha, Bindesh; Morris, Hannah R.; Bier, Mark E.; Whitmore, Paul M.; Vertes, Akos. Minimally invasive monitoring of cellulose degradation by desorption electrospray ionization and laser ablation electrospray ionization mass spectrometry. Analyst 2010,135(9), 2434-2444.
  11. Wu,Zhikun; Lanni, Eric; Chen, Wenqian; Bier, Mark E.; Ly, Danith, and Jin, Rongchao "High Yield, Large Scale Synthesis of Thiolate-Protected Ag7 Clusters" Journal of the American Chemical Society. 2009,131(46), p16672-16674.
  12. Qian, Huifeng; Zhu, Manzhou; Lanni, Eric; Zhu, Yan; Bier, Mark E.; Jin, Rongchao. Conversion of polydisperse Au nanoparticles into monodisperse Au25 nanorods and nanospheres. Journal of Physical Chemistry C 2009,113(41), 17599-17603.
  13. Stephens, Catherine H.; Whitmore, Paul M.; Morris, Hannah R.; Bier, Mark E.. "Hydrolysis of the Amorphous Cellulose in Cotton-Based Paper." Biomacromolecules 2008, 9(4), 1093-1099.
  14. Zhu, Manzhou; Lanni, Eric; Garg, Niti; Bier, Mark E.; Jin, Rongchao. "Kinetically Controlled, High-Yield Synthesis of Au25 Clusters." Journal of the American Chemical Society 2008, 130(4), 1138-1139.
  15. Aksenov, Alexander A.; Bier, Mark E.. "The Analysis of Polystyrene and Polystyrene Aggregates into the Mega Dalton Mass Range by Cryodetection MALDI TOF MS." Journal of the American Society for Mass Spectrometry 2008, 19(2), 219-230.
  16. VanHassel, Emily; Bier, Mark E. "An Electrospray Membrane Probe for the Analysis of Volatile and Semi-volatile Organic Compounds in Water." Rapid Commun. Mass Spectrom. 2007; 21: 413-420.
  17. Datta, Bhaskar; Bier, Mark E.; Roy, Subhadeep and Armitage, Bruce A. "Quadruplex Formation by a Guanine-Rich PNA Oligomer." J. American Chem. Soc. 2005, 127, 4199-4207.
  18. Curten, B.; Kullmann, P.; Bier, M.E.; Kandler, K.; Schmidt, B.F. "Synthesis, Photophysical, Photochemical and Biological Properties of a stable form of caged GABA, 4-[[(2H-1-Benzopyran-2-one-7-amino-4-methoxy)carbonyl]amino] butanoic acid (BC204)" Photochemistry and Photobiology, 2005, 81(3), 641-648.
  19. Yang, Gem and Bier, Mark E. "Investigation of a Rapid Scan on an Electrospray Ion Trap Mass Spectrometer" Anal. Chem. 2005, 77, 1663-1671.
  20. Ramsey, Brian G. and Bier, Mark E. "A LDI Mass Spectrometry Investigation of Triarylboranes and Tri-9-anthrylborane Photolysis Products." Journal of Organometallic Chemistry, 2005, 609, 962-971.
  21. Balasubramani, Manimalha; Bier, Mark E.; Hummel, Susi; Schneider, Wolfgang E. and Halfter, Willi. "Perlecan and its Immunoglobulin like domain IV is abundant in vitreous and serum of the chick embryo." Matrix Biology, 2004, 23, 143-152.
  22. Bier, Mark E.; Yang, Chunguang G.; Grabowski, Joseph J. "The virtual mass spectrometry laboratory and a polymer analysis case study." Polymeric Materials Science and Engineering (2003), 88, 70.
  23. Bier, Mark E. "The basics of MALDI and ESI mass spectrometers for polymer analysis." Polymeric Materials Science and Engineering 2003, 88, 17-18.
  24. Pu, Lixia; Amoscato, Andrew A.; Bier, Mark E.; Lazo, John S. "Dual G1 and G2 Phase Inhibition by a Novel, Selective Cdc25 Inhibitor 6-Chloro-7-(2-morpholin-4-ylethylamino)-quinoline-5, 8-dione." Journal of Biological Chemistry 2002, 277(49), 46877-46885.
  25. Lemus, Ranulfo; Lukinskeine, Lina; Bier, Mark E.; Wisnewski, Adam V.; Redlich, Carrie A.; Karol, Meryl H. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure. Environmental Health Perspectives (2001), 109(11), 1103-1108.
  26. Halfter W; Dong S; Balasubramani M; Bier M. E. "Temporary disruption of the retinal basal lamina and its effect on retinal histogenesis." Developmental biology (2001), 238(1), 79-96.
  27. Dowd, Susan R.; Bier, Mark E.; Patton-Vogt, Jana L. "Turnover of phosphatidylcholine in Saccharomyces cerevisiae: the role of the CDP-choline pathway." Journal of Biological Chemistry (2001), 276(6), 3756-3763.

Book Preface

  1. Richards, Frederic M.; Bier, Mark E.; Hayes, Douglas G.; Hempel, John; Minden, Jonathan S.; Rule, Gordon S.; Brown, William E.; Howard, Gary C. Modern Protein Chemistry (2002), 1-5.

Book Review

  1. Bier, M.E. Book Review of "Liquid Chromatography/Mass Spectrometry Techniques and Applications" by Alfred L Yergey, Charles G. Edmonds, Ivor A.S. Lewis, and Marvin L. Vestal Plenum Press: New York and London. 1990. J. Am. Chem. Soc., 1991, 113 (23).

Mark E. Bier

Research Professor and Director, Center for Molecular Analysis

Department of Chemistry
Carnegie Mellon University
Mellon Institute
4400 Fifth Ave.
Pittsburgh, PA 15213
412-268-3540 (office)
412-268-1061 (fax)

Office: MI 555