Assistant Teaching Professor
Bioorganic Chemistry; fluorescent dyes synthesis; peptides and peptide nucleic acids synthesis; molecular recognition of DNA and G quadruplexes. Natural product chemistry; bioactive natural products; separation methods and spectroscopic analysis.
Courses taught at Córdoba National University, Argentina: Organic Chemistry I and III; Organic Synthesis; Bioorganic Chemistry; Pre-professional Laboratory Practice; Pre-Requisite courses -Supervisor-. Courses taught at Carnegie Mellon University: Organic Chemistry I and II; Laboratory II; Advanced Organic Chemistry; Bioactive Natural Products; Molecular Tools for Chemical and Biological Studies.
My teaching interests are related to the Organic Chemistry field with emphasis on Synthesis and Natural Product Chemistry and allied fields. I am currently teaching Organic Chemistry I (09217, fall), Laboratory II: Organic Synthesis and Analysis (09222, fall), and Molecular Tools for Chemical and Biological Studies (09122, fall), all of them for undergraduate students; Advanced Organic Chemistry (09714, spring) and Bioactive Natural Products (09716, spring) are designed as graduate courses but may also be attended by advanced undergraduate students.
My approach to teaching and curriculum development is strongly geared by my research experience and its practical application to fields of interest such as pharmacy, food industry and research. The design of my courses always evolves from a practical view of the subject matter where I connect the theoretical concepts. I am interested in conveying the student the relevance of chemistry to biology, medicine, food, and its impact to our everyday life.
|1984–1988||Ph.D., Universidad Nacional de Córdoba|
|1981–1983||Pharmacist, Universidad Nacional de Córdoba|
|1977–1981||B.S., Universidad Nacional de Córdoba|
|2011–present||Assistant Teaching Professor, Carnegie Mellon University|
|2007–2011||Research Chemist/Lecturer, Carnegie Mellon University|
|2002–2007||Visiting Assistant Professor, Carnegie Mellon University|
|2001–2002||Assistant Professor, Universidad Nacional de Córdoba|
|2000–2001||Special Faculty, Carnegie Mellon University|
|1999–2000||Assistant Professor, Universidad Nacional de Córdoba|
|1995–1999||Instructor, Universidad Nacional de Córdoba|
|1993–1995||Research Assistant, University of Illinois at Chicago|
|1989–1995||Postdoctoral Fellow, Universidad Nacional de Córdoba|
|1990||Visiting Professor, Universidad Nacional de Catamarca|
|1988||Visiting Professor, Universidad Nacional de Catamarca|
|1998–2001||Investigator, Area: Organic Chemistry; Institution: Argentinean Research Council (Consejo Nacional de Investigaciones Cientificas y Tecnologicas –CONICET-)|
|2014–current||Board member of the Academic Review Board and University Disciplinary Commitee|
|2012–current||Corresponding Secretary Sigma Xi. The Scientific Research Society, CMU chapter|
|2013–2014||Member at large of the Faculty Executive Committee at CMU|
|2012–2014||Senator representing the Faculty of the Chemistry Department|
|2012–2014||Member of the University Student Affairs Council|
|2012–2014||Staff Recognition Committee|
|2000||Premio Felix de Azara, Universidad de Buenos Aires. (Best original research work)|
|1998, Jan.–Feb.||Fellow of the Agencia Española de Cooperación Internacional, Cadiz, España.|
|1995, 1996||Teaching Stimulus Award. Córdoba National University, Argentina|
|1995||Scientific Production Prize, Córdoba National University, Argentina|
|1994-1995||Fellow of the National Research Council of Argentina, University of Illinois at Chicago.|
|1991||Academic Excellence. Consejo de Investigaciones Científicas y Tecnológicas, Córdoba. CONICOR|
|1989–1991||Fellow of the National Research Council of Argentina, Córdoba National University.|
|1984–1989||National Research Council of Argentina -5 year Doctoral Fellowship (Córdoba National University, Argentina).|
|1982||Undergraduate Research Fellowship. Córdoba National University, Argentina|
|1982||Tuition Exception Due to Academic Merits. Córdoba National University, Argentina|
|1981||University Honors, Bachelor in Organic Chemistry. Awarded by the Universidad Nacional de Córdoba to the first and second best GPA in each major|
|2012||Interfraternity Council and Panhellenic Council Role Model Reception, Carnegie Mellon University|
|2009||Alpha Chi Omega invitation in recognition to my impact in their lives, Carnegie Mellon University|
|2008||Kappa Alpha Theta nomination in recognition to my contribution to their education, Carnegie Mellon University|
About 30 peer reviewed publications in the Natural Products and Bioorganic fields. One patent, two book chapters and about 30 presentations at scientific meetings. Selected publications are as follows:
Kimberly J. Zanotti; Gloria L. Silva; Yehuda Creeger; Kelly L. Robertson; Alan S. Waggoner; Peter B. Berget; Bruce A. Armitage.
Blue fluorescent dye-protein complexes based on fluorogenic cyanine dyes and single chain antibody fragments.
(2011) Org. Biomol. Chem. 9, 1012-1020.
Adriana del V. Pacciaroni; María de los Angeles Gette; Marcos Derita; Luis Ariza-Espinar; Roberto R. Gil; Susana A. Zacchino; Gloria L. Silva.
Antigungal Activity of Heterothalamus alienus Metabolites.
(2008) Phytother. Res. 22, 524-528.
T. Constantin; G.L. Silva; K.L. Robertson; T.P. Hamilton; K.M. Fague; A.S. Waggoner; B.A. Armitage.
Synthesis of New Fluorogenic Cyanine Dye and Incorporation into RNA Fluoromodules.
(2008) Organic Lett., 10, 1561-1564.
Gloria L.Silva; Volkan Ediz; David Yaron; Bruce A. Armitage.
Experimental and computational investigation of unsymmetrical cyanine dyes: Understanding torsionally responsive fluorogenic dyes.
(2007) J. Am. Chem. Soc., 129, 5710-5718.
C. Desmarchelier, A. del V. Pacciaroni, D. Abate-Daga, J. Coussio, R.R. Gil, and G.L. Silva.
Antioxidant and Free Radical Scavenging Activities of Misodendrum punctulatum, Myzodendrone and Structurally Related Phenols.
(2005) Phytother. Res., 19, 1043-1047.
Q. Mi, B. Cui, G.L. Silva, D. Lantvit, E. Lin, H. Chai, M. You, M.G. Hollingshead, J.G. Mayo, A.D. Kinghorn, J.M. Pezzuto.
Pervilleine A, a novel Tropane Alkaloid that Reverses the Multidrug-Resistance Phenotype.
(2001) Cancer Res., 61, 4030-4037.
G.L. Silva, B. Cui, D. Chavez, M. You, H.-B. Chai, P. Rosoanaivo, S.M. Lynn, M.J. O’Neill, J.A. Lewis, J.M. Besterman, A. Monks, N.R. Farnsworth, G.A. Cordell, J.M. Pezzuto, A. Kinghorn.
Modulation of the Multidrug-Resistance Phenotype by New Tropane Alkaloid Aromatic Esters from Erythroxylum pervillei.
(2001) J. Nat. Prod., 64, 1514-1520.
Miaomiao Wang, Gloria L. Silva and Bruce A. Armitage.
DNA-Templated formation of a Helical Cyanine Dye J-Aggregate.
(2000) J. Amer. Chem. Soc., 122, 9977-9986.
G.L. Silva, R.R. Gil, B. Cui, H. Chai, T. Santisuk, K. Srisook, V. Reutrakul, P. Tuchinda, S. Sophasan, S. Sujarit, S. Upathan, S.M. Lynn, J.E. Farthing, S.-L. Yang, J.A. Lewis, M.J. O’Neill, N.R. Farnsworth, G.A. Cordell, J.M. Pezzuto and A.D. Kinghorn.
Novel Cytotoxic Ring-A-Seco-Cycloartane Triterpenes from Gardenia coronaria and G. sootepensis.
(1997) Tetrahedron, 53, 529-538.
Gloria L. Silva and Marta E. Goleniowski.
Stimulants and Inhibitors of Psilostachyinolide Production in Callus Culture.
(1994) J. Nat. Prod., 57, 225-229.