Carnegie Mellon University Department of Chemistry
photo of Gloria Silva

Gloria Silva

Assistant Teaching Professor

Carnegie Mellon University

office: DH 1318

(412) 268-9387

ORCID: 0000-0002-0763-8096

Faculty & Research

Gloria Silva

Assistant Teaching Professor

Areas of Specialty

Bioorganic Chemistry; fluorescent dyes synthesis; peptides and peptide nucleic acids synthesis; molecular recognition of DNA and G quadruplexes. Natural product chemistry; bioactive natural products; separation methods and spectroscopic analysis.

Teaching Interests

Courses taught at Córdoba National University, Argentina: Organic Chemistry I and III; Organic Synthesis; Bioorganic Chemistry; Pre-professional Laboratory Practice; Pre-Requisite courses -Supervisor-. Courses taught at Carnegie Mellon University: Organic Chemistry I and II; Laboratory II; Advanced Organic Chemistry; Bioactive Natural Products; Molecular Tools for Chemical and Biological Studies.

Brief Description Teaching Activities

My teaching interests are related to the Organic Chemistry field with emphasis on Synthesis and Natural Product Chemistry and allied fields. I am currently teaching Organic Chemistry I (09217, fall), Laboratory II: Organic Synthesis and Analysis (09222, fall), and Molecular Tools for Chemical and Biological Studies (09122, fall), all of them for undergraduate students; Advanced Organic Chemistry (09714, spring) and Bioactive Natural Products (09716, spring) are designed as graduate courses but may also be attended by advanced undergraduate students.

My approach to teaching and curriculum development is strongly geared by my research experience and its practical application to fields of interest such as pharmacy, food industry and research. The design of my courses always evolves from a practical view of the subject matter where I connect the theoretical concepts. I am interested in conveying the student the relevance of chemistry to biology, medicine, food, and its impact to our everyday life.

Education
Years Degree
1984–1988 Ph.D., Universidad Nacional de Córdoba
1981–1983 Pharmacist, Universidad Nacional de Córdoba
1977–1981 B.S., Universidad Nacional de Córdoba
Appointments
Years Position
2011–present Assistant Teaching Professor, Carnegie Mellon University
2007–2011 Research Chemist/Lecturer, Carnegie Mellon University
2002–2007 Visiting Assistant Professor, Carnegie Mellon University
2001–2002 Assistant Professor, Universidad Nacional de Córdoba
2000–2001 Special Faculty, Carnegie Mellon University
1999–2000 Assistant Professor, Universidad Nacional de Córdoba
1995–1999 Instructor, Universidad Nacional de Córdoba
1993–1995 Research Assistant, University of Illinois at Chicago
1989–1995 Postdoctoral Fellow, Universidad Nacional de Córdoba
1990 Visiting Professor, Universidad Nacional de Catamarca
1988 Visiting Professor, Universidad Nacional de Catamarca
Other Academic Appointments
Years Position
1998–2001 Investigator, Area: Organic Chemistry; Institution: Argentinean Research Council (Consejo Nacional de Investigaciones Cientificas y Tecnologicas –CONICET-)
Activities
Years Activity
2014–current Board member of the Academic Review Board and University Disciplinary Commitee
2012–current Corresponding Secretary Sigma Xi. The Scientific Research Society, CMU chapter
2013–2014 Member at large of the Faculty Executive Committee at CMU
2012–2014 Senator representing the Faculty of the Chemistry Department
2012–2014 Member of the University Student Affairs Council
2012–2014 Staff Recognition Committee
Awards and Distinctions
Years Award
2000 Premio Felix de Azara, Universidad de Buenos Aires. (Best original research work)
1998, Jan.–Feb. Fellow of the Agencia Española de Cooperación Internacional, Cadiz, España.
1995, 1996 Teaching Stimulus Award. Córdoba National University, Argentina
1995 Scientific Production Prize, Córdoba National University, Argentina
1994-1995 Fellow of the National Research Council of Argentina, University of Illinois at Chicago.
1991 Academic Excellence. Consejo de Investigaciones Científicas y Tecnológicas, Córdoba. CONICOR
1989–1991 Fellow of the National Research Council of Argentina, Córdoba National University.
1984–1989 National Research Council of Argentina -5 year Doctoral Fellowship (Córdoba National University, Argentina).
1982 Undergraduate Research Fellowship. Córdoba National University, Argentina
1982 Tuition Exception Due to Academic Merits. Córdoba National University, Argentina
1981 University Honors, Bachelor in Organic Chemistry. Awarded by the Universidad Nacional de Córdoba to the first and second best GPA in each major
Distinction by Students
Years Award
2012 Interfraternity Council and Panhellenic Council Role Model Reception, Carnegie Mellon University
2009 Alpha Chi Omega invitation in recognition to my impact in their lives, Carnegie Mellon University
2008 Kappa Alpha Theta nomination in recognition to my contribution to their education, Carnegie Mellon University
Publications

About 30 peer reviewed publications in the Natural Products and Bioorganic fields. One patent, two book chapters and about 30 presentations at scientific meetings. Selected publications are as follows:

Kimberly J. Zanotti; Gloria L. Silva; Yehuda Creeger; Kelly L. Robertson; Alan S. Waggoner; Peter B. Berget; Bruce A. Armitage.
Blue fluorescent dye-protein complexes based on fluorogenic cyanine dyes and single chain antibody fragments.
(2011) Org. Biomol. Chem. 9, 1012-1020.

Adriana del V. Pacciaroni; María de los Angeles Gette; Marcos Derita; Luis Ariza-Espinar; Roberto R. Gil; Susana A. Zacchino; Gloria L. Silva.
Antigungal Activity of Heterothalamus alienus Metabolites.
(2008) Phytother. Res. 22, 524-528.

T. Constantin; G.L. Silva; K.L. Robertson; T.P. Hamilton; K.M. Fague; A.S. Waggoner; B.A. Armitage.
Synthesis of New Fluorogenic Cyanine Dye and Incorporation into RNA Fluoromodules.
(2008) Organic Lett., 10, 1561-1564.

Gloria L.Silva; Volkan Ediz; David Yaron; Bruce A. Armitage.
Experimental and computational investigation of unsymmetrical cyanine dyes: Understanding torsionally responsive fluorogenic dyes.
(2007) J. Am. Chem. Soc., 129, 5710-5718.

C. Desmarchelier, A. del V. Pacciaroni, D. Abate-Daga, J. Coussio, R.R. Gil, and G.L. Silva.
Antioxidant and Free Radical Scavenging Activities of Misodendrum punctulatum, Myzodendrone and Structurally Related Phenols.
(2005) Phytother. Res., 19, 1043-1047.

Q. Mi, B. Cui, G.L. Silva, D. Lantvit, E. Lin, H. Chai, M. You, M.G. Hollingshead, J.G. Mayo, A.D. Kinghorn, J.M. Pezzuto.
Pervilleine A, a novel Tropane Alkaloid that Reverses the Multidrug-Resistance Phenotype.
(2001) Cancer Res., 61, 4030-4037.

G.L. Silva, B. Cui, D. Chavez, M. You, H.-B. Chai, P. Rosoanaivo, S.M. Lynn, M.J. O’Neill, J.A. Lewis, J.M. Besterman, A. Monks, N.R. Farnsworth, G.A. Cordell, J.M. Pezzuto, A. Kinghorn.
Modulation of the Multidrug-Resistance Phenotype by New Tropane Alkaloid Aromatic Esters from Erythroxylum pervillei.
(2001) J. Nat. Prod., 64, 1514-1520.

Miaomiao Wang, Gloria L. Silva and Bruce A. Armitage.
DNA-Templated formation of a Helical Cyanine Dye J-Aggregate.
(2000) J. Amer. Chem. Soc., 122, 9977-9986.

G.L. Silva, R.R. Gil, B. Cui, H. Chai, T. Santisuk, K. Srisook, V. Reutrakul, P. Tuchinda, S. Sophasan, S. Sujarit, S. Upathan, S.M. Lynn, J.E. Farthing, S.-L. Yang, J.A. Lewis, M.J. O’Neill, N.R. Farnsworth, G.A. Cordell, J.M. Pezzuto and A.D. Kinghorn.
Novel Cytotoxic Ring-A-Seco-Cycloartane Triterpenes from Gardenia coronaria and G. sootepensis.
(1997) Tetrahedron, 53, 529-538.

Gloria L. Silva and Marta E. Goleniowski.
Stimulants and Inhibitors of Psilostachyinolide Production in Callus Culture.
(1994) J. Nat. Prod., 57, 225-229.