Bioorganic chemistry, chemical biology, gene regulation, cellular delivery, protein engineering, molecular self-assembly
Our research program for the past seven years has been focused on the design and development of molecular tools and reagents to regulate gene expression and probe protein localization and dynamics in human somatic and embryonic stem (ES) cells. We are particularly interested in dissecting the genetic blueprint of human ESC and addressing fundamental questions pertaining to the cellular origins of cancer. More recently, we have expanded our research program into other areas including protein design, tissue engineering and molecular self-assembly—taking advantage of the strength of the department, which is interdisciplinary research, combined with our ability to synthesize molecules that integrate all three features of the natural biopolymers: nucleic acids, proteins, and carbohydrates.
|Years||Position or Degree|
|2015–present||Professor of Chemistry, Carnegie Mellon University|
|2007–2015||Associate Professor of Chemistry, Carnegie Mellon University|
|2001–2006||Assistant Professor of Chemistry, Carnegie Mellon University|
|1999–2001||Postdoctoral Fellow, The Scripps Research Institute|
|1998–1999||Postdoctoral Fellow, UC Berkeley|
|1994–1998||Ph.D. in Chemistry, Georgia Institute of Technology|
|1990–1994||B.S. in Chemical Engineering, Georgia Institute of Technology|
|2012||Julius Ashkin Teaching Award, Mellon College of Science|
|2002||Innovative Research Award|
|2002||The Berkman Faculty Development Award|
|2000||Honorarium, Cosmetic Society for Chemists|
|2000||National Institute of Aging Emerging Researcher|
|1999-2001||American Chemical Society Irving Sigal Postdoctoral Fellowship|
|1994||Albert Einstein Award in Astrophysics/Philosophy|
Yeh, J. I., Shivachev, B., Rapireddy, S., Crawford, M. J., Gil, R. R., Du, S., Madrid, M., Ly, D. H. “Crystal structural of chiral γPNA with complementary DNA strand: Insights into the stability and specificity of recognition and conformational preorganization”. J. Am. Chem. Soc. 2010, 132, 10717-10727.
He, G., Rapireddy, S., Bahal, R., Sahu, B., Ly, D. H. “Strand invasion of extended, mixed-sequence B-DNA by γPNAs”. J. Am. Chem. Soc. 2009, 131, 12088-12090.
Dragulescu-Andrasi, A., Rapireddy, S., Frezza, B. M., Gayathri, C., Gil, R. R., Ly, D. H. “A simple γ-backbone modification preorganizes peptide nucleic acid into a helical structure”. J. Am. Chem. Soc. 2006, 128, 10258-10267.
Zhou, P., Wang, M., Fisher, G. W., Waggoner, A., Ly, D. H. “Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA)”. J. Am. Chem. Soc. 2003, 125, 6878-1879.